Alzheimer’s runs in my family. I’m hopeful for better treatments before it hits me. This is good news.
Same here, but I’m going to have to escape the US to have any hope of aquiring medical treatment.
St. Jude, the research hospital that made this discovery, is in the US.
Yes, but any treatment derived from it will very probably be priced out of the reach of most American’s without top shelf insurance.
Apparently, you might at least decrease the risks with lifestyle choices. Especially correct diet, exercise, social factors and sleep.
The suggested changes would also help to reduce the risk for heart attacs, strokes, diabetes and some more.
Especially correct diet, exercise, social factors and sleep
Well fuck
The suggested changes would also help to reduce the risk for heart attacs, strokes, diabetes and some more.
Name one disease that does not benefit from diet, exercise and sleep. Why the fuck do we keep wasting study money on this.
make sure you have all annual vaccinations.
I’m setting up appointments actually this week to get caught up. Who knows when other states start following Florida.
Wow, and of all places a Pediatric research hospital is the source. I hope this opens up some potential clinical treatments.
We still haven’t proven that the amyloids cause Alzheimer’s. They’re a correlation, and it’s possibly the other way around.
They’re a correlation
They actually aren’t. There was a hypothesis presented in 1992 based on some AD pathology images, but by 2008 in truly unbiased studies, they showed no correlation between amyloid load and disease . Many healthy elderly brains are full of amyloid.
But by then, the Amyloid hypothesis became a religion, and supported by some key manuscripts all later proven to be faked. .
Then biogen made a drug that reduced amyloid by 30% in trials…yet no benefit was actually seen in patients who didn’t die of brain bleeds.
In 2011, the Editor of the Journal of Alzheimers disease died in an accident, and this review was then published, because publishing while he was active would have ended his lab.
“For better or worse, the amyloid cascade hypothesis continues to be a conclusion in search of data. As the hypothesis and its various permutations continue to dominate the literature, the extent to which the scientific community clings to the righteousness of the idea with the passage of time and confrontation of contradictory data is striking. In a different context, such a degree of faith would be the envy of any religion.”
Grok, Chat GPT, etc will tell you about amyloid, because their models are trained on a massive pile of bullshit.
Meanwhile, elderly people who maintain their vaccinations have signficantly less dementia..
no correlation between amyloid load and disease . Many healthy elderly brains are full of amyloid.
However many are not, yet IIRC dementia patients always do.
You, sir or madam or they, are a hero. That’s exactly the data I couldn’t remember, but is the reason I felt I had to comment.
Maybe being able to reverse that damage will reveal if that is a cause, or maybe it will eliminate if as a cause. Both would be important steps toward treating it. Inconclusive results would be depressing though, yes.
Sorry, downvoted for bad science. Amyloids have never been proven to be behind Alzheimer’s, and in fact most modern studies show no correlation.
I thought there is a correlation but not a proven causal one
SaveTheTuaHawk@lemmy.ca made some more in-depth comments elsewhere on this post, but in brief, no, none.
The only thing a medicine like this will do is cause brain bleeds and death in the elderly.
Exact, a condition can have neutral secondary and tertiary effects. Just like with aluminium.
What makes a particular protein more tiny than others?
the size
Blimey!
Proteins are made of amino-acids. You can make a protein out of a couple of aminos or a LOT of them.
The sizes, composition and shapes of the proteins then governs their individual function, as there are countless different proteins.
Think of it as Lego. You can build a large spaceship or a small car. Still all Lego, but you can do different things with them.
… all proteins are tiny?
Some are less tiny, some barely count as proteins due to their incredible tinyness
Not all! some are huge consisting of hundreds or even thousands of amino acids.
Others are tiny, consisting of 3-5 amino acids.
Literally microscopic.
Do we know what causes the amyloid beta to start forming into clumps in the first place?
Firstly, whether there are beta amyloid deposits in brain or not does not correlate with AD. Perfectly healthy brains can be full of amyloid.
Secondly, amyloid is increased in response to viral infections, to protect neurons. This is why full vaccinated elderly have signficantly less dementia.
Thirdly, amyloid deposits are used normally to seal the ends of microvasculature, which is why all anti-amyloid drugs to date have a significant risk of causing death due to brain bleeds, this is called Amyloid-Related Imaging Abnormalities (ARIA).
The amyloid hypothesis is bad science. It has been for almost 30 years and only supported by confidence bias and fraudulent work.
Secondly, amyloid is increased in response to viral infections, to protect neurons. This is why full vaccinated elderly have signficantly less dementia.
Sorry I don’t understand this? If beta amyloid deposits in brain do not correlate with AD, why does vaccination make a difference?
I was about to comment the same thing, those first two points are contradictory
So you’re saying fatal strokes cure Alzheimer’s?
(Let the record show this was a joke comment.)
Hey ya’ll, did you hear that fatal strokes cure Alzheimer’s?
How do i get me them fatal strokes!? I figured out how to get raw milk with H5N1 and Ivermectin but I can’t figure this one out? I don’t wanna get Alzheimers and this cure sounds amazing.
Tiny protein dismantles the toxic clumps behind Alzheimer’s
Yeah, so does fluoroantimonic acid.
