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Cake day: June 2nd, 2026

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  • Glad it helps you get by! I hadn’t heard of the rotating antihistamines trick and was curious about the mechanism, so I asked Dr. DuckDuckGo. Could’ve always been some other tolerance mechanism, like faster breakdown of the drug, which rotating might help with. The paper does mention benadryl and a handful of other substances, but it’s also ancient by research standards, so I don’t know if that applies to all antihistamines or if some circumvent tolerance induction somehow.


  • Does rotating them actually work? I thought they all just blocked your histamine receptors, so your body couldn’t care less just which substance did that for expressing more histamine receptors / making more histamine, thereby developing tolerance.

    Edit: Yeah, so I hate to place a nocebo here, but taking a break, not rotating them, seems to be the only effective remedy to anti-histamine tolerance. That is, if taking a break is tolerable, of course. I don’t know if that has to be said but please take medical advice from your health care professional of choice and not from a lemmy comment.

    Tolerance developed to one antihistamine extended to others, even though the chemical relationship was not close. Return of pharmacologic response to an antihistamine after discontinuance of the drug takes from 3 to 14 days.

    https://www.jacionline.org/article/0021-8707(51)90033-0/fulltext





  • TLDR: Open package repositories without some approval and oversight system, like AUR, will have even more problems in the future due to advanced coding AI and malicious foreign hackers.

    Edit: Please normalize TLDR’s on bot posts with just a link.

    Edit 2: I have been rightfully informed that this is not a bot post. I still think links should not be posted without a tiny abstract, one might say: a TLDR.

    I have also been informed that the text does not spell out “foreign”. This is correct. The text does say

    Not all of the packaging issues are as bad as the initial wave of trying to steal credentials, some are just adding ridiculous messages in Russian.

    This implies but does not establish the nationality of attackers. While Arch has contributors from all over the world, it is commonly cited as being a Canadian distribution (example, see below). https://distrowatch.com/table-mobile.php?distribution=arch