𝕽𝖆𝖉𝖎𝖈𝖆𝖑 𝕽𝖊𝖇𝖊𝖑

“𝖘𝖊𝖛𝖊𝖓𝖙𝖞-𝖙𝖜𝖔 𝖛𝖎𝖗𝖌𝖎𝖓𝖘, 𝖈𝖆𝖓 𝖓𝖊𝖛𝖊𝖗 𝖘𝖙𝖔𝖕 𝖆 𝖜𝖆𝖗, 𝖇𝖚𝖙 𝖆 𝖍𝖚𝖓𝖉𝖗𝖊𝖉-𝖙𝖍𝖔𝖚𝖘𝖆𝖓𝖉 𝖍𝖔𝖔𝖐𝖊𝖗𝖘, 𝖈𝖔𝖚𝖑𝖉 𝖇𝖊𝖆𝖙 𝖙𝖍𝖊 𝖒𝖆𝖗𝖎𝖓𝖊 𝖈𝖔𝖗𝖊” - 𝖓𝖔𝖋𝖝

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Cake day: June 6th, 2025

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  • Thanks for the reply, it made me dig a bit deeper into this treatment (Casgevy) methodology and I learned some radical things about it! But the term gene editing in molecular/microbiology always refers to DNA, so these changes will be present in all future cells. Knowing the treatment used gene editing, I incorrectly assumed they just cut out the genetic sequence causing sickle cell. However, they edited the patients stem cells and reinfused them to create a permanent population of red blood cells with both the original sickle cell and fetal red blood cell traits! This works since fetal red blood cells don’t sickle due to their cell structure, meaning the sickle cell mutation remains in the patient’s DNA, so the edited cells still produce the trait to help with malaria.