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Joined 2 years ago
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Cake day: June 23rd, 2023

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  • I think I remember hearing methanol got most of its bad rep (over IPA) because it was commonly produced with the ethanol when moonshine was made by inexperienced people. During prohibition, people would go to these inexperienced distillers because of the low cost (or even try doing it themselves) and get sick.

    It is also used to “denature” (make unfit for consumption) ethanol for industrial use to be exempt from alcohol taxes. Bittering agents are more common now though, especially when the product is consumer facing and the residue left by the agent isn’t important.














  • https://pmc.ncbi.nlm.nih.gov/articles/PMC8909049/ (2022 Feb 25)

    In summary, mice were intragastrically administered with CAP at three doses to evaluate the effects of CAP on GI health. The results showed that administration of 40 mg/kg CAP did not have significant negative effects on the GI tract in mice, while 60 and 80 mg/kg CAP caused GI injury by damaging GI tissues and decreasing the levels of anti-inflammatory cytokines (IL-10). Inflammation and histopathological changes were significant in the jejunum, ileum, and colon, but only slight in the stomach. CAP increased serum SP and CGRP levels in a dose-dependent manner, which may induce an immune response and visceral pain. The levels of cecal SCFAs also significantly changed in the 80 mg/kg CAP-treated groups. These effects of CAP might be related to the regulation of gut microbiota, especially Bifidobacterium, Lactobacillus, Faecalibacterium, and Butyricimonas. Moreover, the underlying mechanism of the correlation between serum neuropeptides and specific gut microbiota needs to be studied, suggesting that probiotics, as members of the gut microbiota, may be an alternative in relieving CAP-induced GI injury. These data will reveal the effects of CAP on GI health, provide insight into the experimental model of CAP-induced GI injury, and enrich the correlation analysis between CAP ingestion and gut microbiota.

    It looks like it’s still being studied. For now, I guess you can resolve it to being an irritant when ingested in larger quantities than your body likes.